Drug interactions
Bupropion-naltrexone + Selegiline transdermal
Severity: Contraindicated
Bupropion-naltrexone and Selegiline transdermal: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining bupropion with an MAO inhibitor such as transdermal selegiline can cause hypertensive reactions and excessive dopaminergic and noradrenergic stimulation. The labeling for bupropion contraindicates use with MAOIs.
What this interaction means in plain words
Bupropion-naltrexone and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Bupropion inhibits dopamine and norepinephrine reuptake while MAO inhibition reduces their breakdown, additively increasing catecholamine activity.
What to do
Do not coadminister; allow at least 14 days between stopping the MAOI and starting bupropion-naltrexone, and the reverse sequence similarly per labeling.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Frequently asked questions
Can I take Bupropion-naltrexone with Selegiline transdermal?
MediHelp rates the interaction as contraindicated. Bupropion-naltrexone and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining bupropion with an MAO inhibitor such as transdermal selegiline can cause hypertensive reactions and excessive dopaminergic and noradrenergic stimulation. The labeling for bupropion contraindicates use with MAOIs.
How serious is the interaction between Bupropion-naltrexone and Selegiline transdermal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; allow at least 14 days between stopping the MAOI and starting bupropion-naltrexone, and the reverse sequence similarly per labeling.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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