Drug interactions
Bupropion-naltrexone + Trifluoperazine
Severity: Moderate
Bupropion-naltrexone and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both bupropion and phenothiazine antipsychotics such as trifluoperazine can lower the seizure threshold, so using them together may increase the chance of seizures. Bupropion's CYP2D6 inhibition may also modestly raise exposure to some antipsychotics.
What this interaction means in plain words
Bupropion-naltrexone and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive lowering of seizure threshold, with possible added CYP2D6 inhibition by bupropion affecting antipsychotic clearance.
What to do
Keep the bupropion dose as low as effective and avoid it in patients with other seizure risk factors. Monitor for seizures and antipsychotic adverse effects such as extrapyramidal symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Frequently asked questions
Can I take Bupropion-naltrexone with Trifluoperazine?
MediHelp rates the interaction as moderate. Bupropion-naltrexone and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both bupropion and phenothiazine antipsychotics such as trifluoperazine can lower the seizure threshold, so using them together may increase the chance of seizures. Bupropion's CYP2D6 inhibition may also modestly raise exposure to some antipsychotics.
How serious is the interaction between Bupropion-naltrexone and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep the bupropion dose as low as effective and avoid it in patients with other seizure risk factors. Monitor for seizures and antipsychotic adverse effects such as extrapyramidal symptoms.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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