Drug interactions
Buspirone + Istradefylline
Severity: Moderate
Buspirone and Istradefylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At 40 mg daily, istradefylline raises exposure to CYP3A4 substrates. Buspirone levels may therefore increase, causing more dizziness, drowsiness and nausea.
What this interaction means in plain words
Buspirone and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buspirone belongs to Central Nervous System; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline inhibits CYP3A4 at higher doses, reducing buspirone metabolism.
What to do
If istradefylline is used at 40 mg daily, consider a lower buspirone dose and monitor tolerability. Dose adjustment is less likely to be needed at 20 mg daily.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Buspirone and Istradefylline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Buspirone with Istradefylline?
MediHelp rates the interaction as moderate. Buspirone and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At 40 mg daily, istradefylline raises exposure to CYP3A4 substrates. Buspirone levels may therefore increase, causing more dizziness, drowsiness and nausea.
How serious is the interaction between Buspirone and Istradefylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If istradefylline is used at 40 mg daily, consider a lower buspirone dose and monitor tolerability. Dose adjustment is less likely to be needed at 20 mg daily.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
