Drug interactions
Buspirone + Nifedipine
Severity: Minor
Buspirone and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buspirone is extensively metabolized by CYP3A4 and nifedipine may modestly raise its levels. This may increase dizziness, drowsiness or nausea.
What this interaction means in plain words
Buspirone and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Buspirone belongs to Central Nervous System; Nifedipine belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP3A4-mediated buspirone first-pass metabolism.
What to do
Monitor for buspirone adverse effects and lower the dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Buspirone with Nifedipine?
MediHelp rates the interaction as minor. Buspirone and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Buspirone is extensively metabolized by CYP3A4 and nifedipine may modestly raise its levels. This may increase dizziness, drowsiness or nausea.
How serious is the interaction between Buspirone and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for buspirone adverse effects and lower the dose if they occur.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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