Drug interactions
Buspirone + Nilotinib
Severity: Moderate
Buspirone and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib is a moderate CYP3A4 inhibitor and may raise buspirone plasma concentrations. Higher exposure can cause dizziness, drowsiness, nausea and headache.
What this interaction means in plain words
Buspirone and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buspirone belongs to Central Nervous System; Nilotinib belongs to Oncology.
Why it happens
Nilotinib inhibits CYP3A4-mediated first-pass and systemic metabolism of buspirone.
What to do
Start buspirone at a low dose and titrate according to tolerability and anxiolytic response. Reduce the buspirone dose if excessive sedation or dizziness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Buspirone with Nilotinib?
MediHelp rates the interaction as moderate. Buspirone and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib is a moderate CYP3A4 inhibitor and may raise buspirone plasma concentrations. Higher exposure can cause dizziness, drowsiness, nausea and headache.
How serious is the interaction between Buspirone and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start buspirone at a low dose and titrate according to tolerability and anxiolytic response. Reduce the buspirone dose if excessive sedation or dizziness occurs.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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