Drug interactions
Buspirone + Rufinamide
Severity: Minor
Buspirone and Rufinamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rufinamide is a weak CYP3A4 inducer and may modestly lower buspirone levels. A clinically important loss of effect is not expected in most patients. Both drugs also cause dizziness and somnolence.
What this interaction means in plain words
Buspirone and Rufinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Buspirone belongs to Central Nervous System; Rufinamide belongs to Central Nervous System.
Why it happens
Weak induction of CYP3A4 by rufinamide increases buspirone metabolism.
What to do
No routine dose change is needed. Check anxiolytic response and tolerability after rufinamide is started or its dose is altered.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Other interactions of Rufinamide
- Carbamazepine + Rufinamide Moderate
- Desogestrel-ethinyl estradiol + Rufinamide Moderate
- Dronedarone + Rufinamide Moderate
- Esketamine + Rufinamide Moderate
- Ethinyl estradiol-drospirenone + Rufinamide Moderate
- Ethinyl estradiol-levonorgestrel + Rufinamide Moderate
Frequently asked questions
Can I take Buspirone with Rufinamide?
MediHelp rates the interaction as minor. Buspirone and Rufinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rufinamide is a weak CYP3A4 inducer and may modestly lower buspirone levels. A clinically important loss of effect is not expected in most patients. Both drugs also cause dizziness and somnolence.
How serious is the interaction between Buspirone and Rufinamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Check anxiolytic response and tolerability after rufinamide is started or its dose is altered.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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