Drug interactions
Busulfan + Cisplatin
Severity: Moderate
Busulfan and Cisplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can suppress the bone marrow, so combined use may cause deeper and longer cytopenias. This increases the risk of infection and bleeding.
What this interaction means in plain words
Busulfan and Cisplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Busulfan belongs to Oncology; Cisplatin belongs to Oncology.
Why it happens
Additive myelosuppression from two cytotoxic agents.
What to do
Monitor complete blood counts frequently and adjust doses or delay cycles based on recovery. Also monitor renal function because of cisplatin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Other interactions of Busulfan
- Busulfan + Carboplatin Major
- Busulfan + Chlorambucil Major
- Busulfan + Cyclophosphamide Major
- Busulfan + Fingolimod Major
- Busulfan + Hydroxycarbamide Major
- Busulfan + Ifosfamide Major
Frequently asked questions
Can I take Busulfan with Cisplatin?
MediHelp rates the interaction as moderate. Busulfan and Cisplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can suppress the bone marrow, so combined use may cause deeper and longer cytopenias. This increases the risk of infection and bleeding.
How serious is the interaction between Busulfan and Cisplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and adjust doses or delay cycles based on recovery. Also monitor renal function because of cisplatin.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
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