Drug interactions
Busulfan + Ethinyl estradiol-drospirenone
Severity: Minor
Busulfan and Ethinyl estradiol-drospirenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone is unlikely to alter busulfan exposure in practice. Busulfan is cleared mainly by glutathione conjugation, so CYP3A4 effects are of limited relevance.
What this interaction means in plain words
Busulfan and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Busulfan belongs to Oncology; Ethinyl estradiol-drospirenone belongs to Endocrine.
Why it happens
Theoretical weak CYP3A4 inhibition with minor relevance to busulfan clearance.
What to do
No specific action is needed; continue standard busulfan monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Busulfan
- Busulfan + Carboplatin Major
- Busulfan + Chlorambucil Major
- Busulfan + Cyclophosphamide Major
- Busulfan + Fingolimod Major
- Busulfan + Hydroxycarbamide Major
- Busulfan + Ifosfamide Major
Frequently asked questions
Can I take Busulfan with Ethinyl estradiol-drospirenone?
MediHelp rates the interaction as minor. Busulfan and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone is unlikely to alter busulfan exposure in practice. Busulfan is cleared mainly by glutathione conjugation, so CYP3A4 effects are of limited relevance.
How serious is the interaction between Busulfan and Ethinyl estradiol-drospirenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed; continue standard busulfan monitoring.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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