Drug interactions
Busulfan + Ribociclib
Severity: Moderate
Busulfan and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Busulfan is partly metabolized by CYP3A4, and ribociclib inhibits this enzyme, so busulfan exposure may increase. Because busulfan has a narrow therapeutic window, higher exposure may increase myelosuppression and hepatic veno-occlusive disease risk.
What this interaction means in plain words
Busulfan and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Busulfan belongs to Oncology; Ribociclib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated busulfan metabolism by ribociclib.
What to do
Avoid ribociclib during busulfan conditioning if possible. Otherwise monitor blood counts and busulfan levels where available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Busulfan
- Busulfan + Carboplatin Major
- Busulfan + Chlorambucil Major
- Busulfan + Cyclophosphamide Major
- Busulfan + Fingolimod Major
- Busulfan + Hydroxycarbamide Major
- Busulfan + Ifosfamide Major
Frequently asked questions
Can I take Busulfan with Ribociclib?
MediHelp rates the interaction as moderate. Busulfan and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Busulfan is partly metabolized by CYP3A4, and ribociclib inhibits this enzyme, so busulfan exposure may increase. Because busulfan has a narrow therapeutic window, higher exposure may increase myelosuppression and hepatic veno-occlusive disease risk.
How serious is the interaction between Busulfan and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ribociclib during busulfan conditioning if possible. Otherwise monitor blood counts and busulfan levels where available.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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