Drug interactions
Butabarbital + Cinacalcet
Severity: Moderate
Butabarbital and Cinacalcet: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butabarbital is a barbiturate and an inducer of CYP3A4 and other enzymes, which may lower cinacalcet concentrations. Reduced exposure could lessen control of hyperparathyroidism.
What this interaction means in plain words
Butabarbital and Cinacalcet can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Enzyme induction by barbiturates increases cinacalcet metabolism.
What to do
Monitor serum calcium and PTH after starting or stopping the barbiturate. Increase cinacalcet dose if response is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Frequently asked questions
Can I take Butabarbital with Cinacalcet?
MediHelp rates the interaction as moderate. Butabarbital and Cinacalcet can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butabarbital is a barbiturate and an inducer of CYP3A4 and other enzymes, which may lower cinacalcet concentrations. Reduced exposure could lessen control of hyperparathyroidism.
How serious is the interaction between Butabarbital and Cinacalcet?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and PTH after starting or stopping the barbiturate. Increase cinacalcet dose if response is lost.
What other medicines interact with Cinacalcet?
MediHelp also lists interactions of Cinacalcet with, for example, Etelcalcetide, Eliglustat, Metoclopramide. The full list is on the Cinacalcet page.
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