Drug interactions
Butabarbital + Clarithromycin
Severity: Moderate
Butabarbital and Clarithromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butabarbital is an enzyme inducer that may lower clarithromycin concentrations. This could reduce antibacterial efficacy, particularly in serious infections.
What this interaction means in plain words
Butabarbital and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 increases clarithromycin metabolism.
What to do
Monitor clinical response to clarithromycin, and consider an alternative antibiotic that is not a CYP3A4 substrate if the infection is serious.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Butabarbital with Clarithromycin?
MediHelp rates the interaction as moderate. Butabarbital and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butabarbital is an enzyme inducer that may lower clarithromycin concentrations. This could reduce antibacterial efficacy, particularly in serious infections.
How serious is the interaction between Butabarbital and Clarithromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to clarithromycin, and consider an alternative antibiotic that is not a CYP3A4 substrate if the infection is serious.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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