Drug interactions
Butabarbital + Clomipramine
Severity: Moderate
Butabarbital and Clomipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butabarbital induces hepatic enzymes and may lower clomipramine concentrations, reducing antidepressant effect. Both drugs also depress the CNS, so sedation may increase.
What this interaction means in plain words
Butabarbital and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate induction of CYP1A2 and CYP3A4 metabolism of clomipramine, plus additive CNS depression.
What to do
Monitor clinical response and increase clomipramine dose if needed. Watch for sedation and re-adjust the dose when the barbiturate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Butabarbital with Clomipramine?
MediHelp rates the interaction as moderate. Butabarbital and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butabarbital induces hepatic enzymes and may lower clomipramine concentrations, reducing antidepressant effect. Both drugs also depress the CNS, so sedation may increase.
How serious is the interaction between Butabarbital and Clomipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and increase clomipramine dose if needed. Watch for sedation and re-adjust the dose when the barbiturate is stopped.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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