Drug interactions
Butabarbital + Dronabinol
Severity: Moderate
Butabarbital and Dronabinol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butabarbital induces hepatic enzymes and may lower dronabinol concentrations, reducing its antiemetic or appetite effect. Both drugs also cause CNS depression, so additive sedation is possible.
What this interaction means in plain words
Butabarbital and Dronabinol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate induction of CYP3A4 and CYP2C9 increases dronabinol clearance, plus additive CNS depression.
What to do
Monitor for reduced dronabinol efficacy and increase the dose if needed. Watch for excessive sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
Frequently asked questions
Can I take Butabarbital with Dronabinol?
MediHelp rates the interaction as moderate. Butabarbital and Dronabinol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butabarbital induces hepatic enzymes and may lower dronabinol concentrations, reducing its antiemetic or appetite effect. Both drugs also cause CNS depression, so additive sedation is possible.
How serious is the interaction between Butabarbital and Dronabinol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced dronabinol efficacy and increase the dose if needed. Watch for excessive sedation.
What other medicines interact with Dronabinol?
MediHelp also lists interactions of Dronabinol with, for example, Cefotetan, Disulfiram, Midazolam intranasal. The full list is on the Dronabinol page.
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