Drug interactions
Butabarbital + Eplerenone
Severity: Moderate
Butabarbital and Eplerenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates are enzyme inducers that increase CYP3A4 activity, and eplerenone is cleared mainly by CYP3A4. Exposure to eplerenone may fall and its blood pressure or cardiac effect may be lost.
What this interaction means in plain words
Butabarbital and Eplerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 by butabarbital, increasing eplerenone metabolism.
What to do
Monitor blood pressure and clinical response, and increase the eplerenone dose if needed. Reassess the dose when the barbiturate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Frequently asked questions
Can I take Butabarbital with Eplerenone?
MediHelp rates the interaction as moderate. Butabarbital and Eplerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates are enzyme inducers that increase CYP3A4 activity, and eplerenone is cleared mainly by CYP3A4. Exposure to eplerenone may fall and its blood pressure or cardiac effect may be lost.
How serious is the interaction between Butabarbital and Eplerenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and clinical response, and increase the eplerenone dose if needed. Reassess the dose when the barbiturate is stopped.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
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