Drug interactions
Butabarbital + Fluphenazine
Severity: Moderate
Butabarbital and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the CNS, so together they can cause excessive sedation, impaired coordination and respiratory depression. Barbiturates also induce hepatic enzymes and may lower fluphenazine concentrations over time.
What this interaction means in plain words
Butabarbital and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with barbiturate-mediated enzyme induction possibly reducing phenothiazine levels.
What to do
Monitor sedation and psychiatric response, and reduce doses if oversedation occurs. Watch for loss of antipsychotic efficacy during prolonged barbiturate use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Butabarbital with Fluphenazine?
MediHelp rates the interaction as moderate. Butabarbital and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the CNS, so together they can cause excessive sedation, impaired coordination and respiratory depression. Barbiturates also induce hepatic enzymes and may lower fluphenazine concentrations over time.
How serious is the interaction between Butabarbital and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and psychiatric response, and reduce doses if oversedation occurs. Watch for loss of antipsychotic efficacy during prolonged barbiturate use.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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