Drug interactions
Butabarbital + Haloperidol
Severity: Moderate
Butabarbital and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates and haloperidol both cause CNS depression, so combined use may increase sedation, impaired psychomotor performance and respiratory depression. Barbiturates may also induce haloperidol metabolism and lower its levels.
What this interaction means in plain words
Butabarbital and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with possible CYP enzyme induction by butabarbital.
What to do
Monitor sedation and psychiatric response, and adjust haloperidol dose if efficacy falls. Advise patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Butabarbital with Haloperidol?
MediHelp rates the interaction as moderate. Butabarbital and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates and haloperidol both cause CNS depression, so combined use may increase sedation, impaired psychomotor performance and respiratory depression. Barbiturates may also induce haloperidol metabolism and lower its levels.
How serious is the interaction between Butabarbital and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and psychiatric response, and adjust haloperidol dose if efficacy falls. Advise patients to avoid driving and alcohol.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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