Drug interactions
Butabarbital + Liposomal doxorubicin
Severity: Moderate
Butabarbital and Liposomal doxorubicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce CYP3A4 and other enzymes and may lower doxorubicin exposure, with potential loss of efficacy. The effect is uncertain because CYP3A4 is a minor clearance pathway.
What this interaction means in plain words
Butabarbital and Liposomal doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Enzyme induction by butabarbital increases doxorubicin metabolism.
What to do
Use a non-barbiturate sedative or hypnotic when possible. If combined, monitor for reduced tumor response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Frequently asked questions
Can I take Butabarbital with Liposomal doxorubicin?
MediHelp rates the interaction as moderate. Butabarbital and Liposomal doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce CYP3A4 and other enzymes and may lower doxorubicin exposure, with potential loss of efficacy. The effect is uncertain because CYP3A4 is a minor clearance pathway.
How serious is the interaction between Butabarbital and Liposomal doxorubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-barbiturate sedative or hypnotic when possible. If combined, monitor for reduced tumor response.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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