Drug interactions
Butabarbital + Lovastatin
Severity: Moderate
Butabarbital and Lovastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butabarbital may lower lovastatin concentrations through enzyme induction. This could reduce the cholesterol-lowering effect.
What this interaction means in plain words
Butabarbital and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate induction of CYP3A4 increases lovastatin metabolism.
What to do
Monitor the lipid panel and increase lovastatin dose if needed, or use a statin not dependent on CYP3A4.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Frequently asked questions
Can I take Butabarbital with Lovastatin?
MediHelp rates the interaction as moderate. Butabarbital and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butabarbital may lower lovastatin concentrations through enzyme induction. This could reduce the cholesterol-lowering effect.
How serious is the interaction between Butabarbital and Lovastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the lipid panel and increase lovastatin dose if needed, or use a statin not dependent on CYP3A4.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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