Drug interactions
Butabarbital + Lurasidone
Severity: Major
Butabarbital and Lurasidone: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butabarbital is a sedative barbiturate that adds to the CNS depression of lurasidone. It is also a CYP3A4 inducer and may lower lurasidone concentrations, reducing its antipsychotic effect.
What this interaction means in plain words
Butabarbital and Lurasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS depression plus CYP3A4 induction by the barbiturate, which increases lurasidone clearance.
What to do
Avoid long-term use together, since strong CYP3A4 inducers are contraindicated with lurasidone. If a barbiturate is needed, monitor psychiatric response and sedation and consider an alternative.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Butabarbital with Lurasidone?
MediHelp rates the interaction as major. Butabarbital and Lurasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Butabarbital is a sedative barbiturate that adds to the CNS depression of lurasidone. It is also a CYP3A4 inducer and may lower lurasidone concentrations, reducing its antipsychotic effect.
How serious is the interaction between Butabarbital and Lurasidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid long-term use together, since strong CYP3A4 inducers are contraindicated with lurasidone. If a barbiturate is needed, monitor psychiatric response and sedation and consider an alternative.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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