Drug interactions
Butabarbital + Metoprolol
Severity: Moderate
Butabarbital and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butabarbital induces hepatic enzymes and can reduce metoprolol concentrations, potentially weakening its effect on heart rate and blood pressure. Metoprolol is extensively metabolized, so this effect may be meaningful.
What this interaction means in plain words
Butabarbital and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of hepatic CYP enzymes increases metoprolol metabolism and lowers its exposure.
What to do
Monitor heart rate and blood pressure when butabarbital is started or stopped. Increase the metoprolol dose if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Butabarbital with Metoprolol?
MediHelp rates the interaction as moderate. Butabarbital and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butabarbital induces hepatic enzymes and can reduce metoprolol concentrations, potentially weakening its effect on heart rate and blood pressure. Metoprolol is extensively metabolized, so this effect may be meaningful.
How serious is the interaction between Butabarbital and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when butabarbital is started or stopped. Increase the metoprolol dose if response is inadequate.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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