Drug interactions
Butabarbital + Paliperidone
Severity: Moderate
Butabarbital and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates and paliperidone both depress the CNS, increasing drowsiness, impaired coordination and hypotension. Butabarbital is also a CYP inducer and may reduce paliperidone exposure over time.
What this interaction means in plain words
Butabarbital and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with possible enzyme and P-gp induction by the barbiturate lowering paliperidone levels.
What to do
Monitor for sedation and orthostasis, and for loss of antipsychotic effect. Adjust the paliperidone dose according to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Butabarbital with Paliperidone?
MediHelp rates the interaction as moderate. Butabarbital and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates and paliperidone both depress the CNS, increasing drowsiness, impaired coordination and hypotension. Butabarbital is also a CYP inducer and may reduce paliperidone exposure over time.
How serious is the interaction between Butabarbital and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostasis, and for loss of antipsychotic effect. Adjust the paliperidone dose according to clinical response.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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