Drug interactions
Butabarbital + Perphenazine
Severity: Moderate
Butabarbital and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates and phenothiazines both depress the CNS, so together they can cause excessive sedation, impaired coordination and respiratory depression. Barbiturates may also induce hepatic enzymes and lower perphenazine exposure over time.
What this interaction means in plain words
Butabarbital and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with possible barbiturate-mediated CYP induction lowering perphenazine levels.
What to do
Monitor sedation and psychiatric response, and use the lowest effective doses. Counsel patients to avoid alcohol and driving until the effect is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Butabarbital with Perphenazine?
MediHelp rates the interaction as moderate. Butabarbital and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates and phenothiazines both depress the CNS, so together they can cause excessive sedation, impaired coordination and respiratory depression. Barbiturates may also induce hepatic enzymes and lower perphenazine exposure over time.
How serious is the interaction between Butabarbital and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and psychiatric response, and use the lowest effective doses. Counsel patients to avoid alcohol and driving until the effect is known.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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