Drug interactions
Butabarbital + Piroxicam
Severity: Minor
Butabarbital and Piroxicam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes, which may increase the metabolism of piroxicam and lower its exposure. This could reduce its analgesic or anti-inflammatory effect.
What this interaction means in plain words
Butabarbital and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate induction of hepatic enzymes including CYP2C9, which metabolizes piroxicam.
What to do
Assess therapeutic response to piroxicam and increase the dose only if needed within the labeled maximum.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Butabarbital with Piroxicam?
MediHelp rates the interaction as minor. Butabarbital and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates induce hepatic enzymes, which may increase the metabolism of piroxicam and lower its exposure. This could reduce its analgesic or anti-inflammatory effect.
How serious is the interaction between Butabarbital and Piroxicam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess therapeutic response to piroxicam and increase the dose only if needed within the labeled maximum.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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