Drug interactions
Butabarbital + Saxagliptin
Severity: Moderate
Butabarbital and Saxagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce CYP3A4 and may lower saxagliptin exposure, although its active metabolite is formed by the same pathway. Loss of glycemic effect is possible with chronic use.
What this interaction means in plain words
Butabarbital and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4/5 by barbiturates increases saxagliptin metabolism.
What to do
Monitor glucose and HbA1c if chronic butabarbital is used. Consider an alternative antidiabetic if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Butabarbital with Saxagliptin?
MediHelp rates the interaction as moderate. Butabarbital and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce CYP3A4 and may lower saxagliptin exposure, although its active metabolite is formed by the same pathway. Loss of glycemic effect is possible with chronic use.
How serious is the interaction between Butabarbital and Saxagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c if chronic butabarbital is used. Consider an alternative antidiabetic if control is lost.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
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