Drug interactions
Butabarbital + Solifenacin
Severity: Moderate
Butabarbital and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce CYP3A4 and may lower solifenacin concentrations, reducing efficacy for overactive bladder. The effect can persist for some time after the barbiturate is stopped.
What this interaction means in plain words
Butabarbital and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 increases solifenacin clearance.
What to do
Monitor urinary symptom response and adjust the solifenacin dose or choose an alternative if efficacy is lost; reassess when the barbiturate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Butabarbital and Solifenacin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Solifenacin
Frequently asked questions
Can I take Butabarbital with Solifenacin?
MediHelp rates the interaction as moderate. Butabarbital and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce CYP3A4 and may lower solifenacin concentrations, reducing efficacy for overactive bladder. The effect can persist for some time after the barbiturate is stopped.
How serious is the interaction between Butabarbital and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urinary symptom response and adjust the solifenacin dose or choose an alternative if efficacy is lost; reassess when the barbiturate is stopped.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
