Drug interactions
Butalbital + Clarithromycin
Severity: Minor
Butalbital and Clarithromycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that may induce CYP3A4 and reduce clarithromycin exposure. Treatment response may be reduced, though short-term butalbital use has limited effect.
What this interaction means in plain words
Butalbital and Clarithromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Induction of CYP3A4 increases clarithromycin clearance.
What to do
No routine change is needed for short-term use. Monitor clinical response if butalbital is used regularly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Butalbital with Clarithromycin?
MediHelp rates the interaction as minor. Butalbital and Clarithromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butalbital is a barbiturate that may induce CYP3A4 and reduce clarithromycin exposure. Treatment response may be reduced, though short-term butalbital use has limited effect.
How serious is the interaction between Butalbital and Clarithromycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed for short-term use. Monitor clinical response if butalbital is used regularly.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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