Drug interactions
Butalbital + Clomipramine
Severity: Moderate
Butalbital and Clomipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that can induce hepatic enzymes and lower clomipramine exposure, with possible loss of antidepressant effect. Both agents are also sedating.
What this interaction means in plain words
Butalbital and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate induction of CYP1A2 and CYP3A4 metabolism of clomipramine, plus additive CNS depression.
What to do
Monitor antidepressant response and titrate clomipramine upward if needed. Monitor sedation and avoid frequent or prolonged butalbital use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Butalbital with Clomipramine?
MediHelp rates the interaction as moderate. Butalbital and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate that can induce hepatic enzymes and lower clomipramine exposure, with possible loss of antidepressant effect. Both agents are also sedating.
How serious is the interaction between Butalbital and Clomipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor antidepressant response and titrate clomipramine upward if needed. Monitor sedation and avoid frequent or prolonged butalbital use.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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