Drug interactions
Butalbital + Dapsone
Severity: Minor
Butalbital and Dapsone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that can induce hepatic enzymes and may lower dapsone concentrations. The effect is likely minor with intermittent use but may matter with frequent dosing.
What this interaction means in plain words
Butalbital and Dapsone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Butalbital induces CYP3A4, accelerating dapsone metabolism.
What to do
Monitor for loss of dapsone efficacy if butalbital is used regularly. Adjust the dapsone dose according to response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Frequently asked questions
Can I take Butalbital with Dapsone?
MediHelp rates the interaction as minor. Butalbital and Dapsone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butalbital is a barbiturate that can induce hepatic enzymes and may lower dapsone concentrations. The effect is likely minor with intermittent use but may matter with frequent dosing.
How serious is the interaction between Butalbital and Dapsone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of dapsone efficacy if butalbital is used regularly. Adjust the dapsone dose according to response.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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