Drug interactions
Butalbital + Esmolol
Severity: Minor
Butalbital and Esmolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital can induce hepatic enzymes, which lowers levels of hepatically metabolised beta-blockers. Esmolol is broken down by red blood cell esterases, so a clinically relevant reduction is unlikely.
What this interaction means in plain words
Butalbital and Esmolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Enzyme induction by barbiturates is theoretically relevant, but esmolol is cleared by esterases rather than CYP enzymes.
What to do
No empirical dose adjustment is needed. Titrate esmolol to the clinical response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Frequently asked questions
Can I take Butalbital with Esmolol?
MediHelp rates the interaction as minor. Butalbital and Esmolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butalbital can induce hepatic enzymes, which lowers levels of hepatically metabolised beta-blockers. Esmolol is broken down by red blood cell esterases, so a clinically relevant reduction is unlikely.
How serious is the interaction between Butalbital and Esmolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose adjustment is needed. Titrate esmolol to the clinical response.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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