Drug interactions
Butalbital + Etonogestrel
Severity: Moderate
Butalbital and Etonogestrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate with enzyme-inducing potential and may reduce etonogestrel exposure, risking reduced contraceptive efficacy. The effect is likely greater with frequent or prolonged use.
What this interaction means in plain words
Butalbital and Etonogestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 by butalbital increases etonogestrel metabolism.
What to do
Add a barrier method if butalbital is used regularly, and consider a non-hormonal method for long-term use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etonogestrel
Frequently asked questions
Can I take Butalbital with Etonogestrel?
MediHelp rates the interaction as moderate. Butalbital and Etonogestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate with enzyme-inducing potential and may reduce etonogestrel exposure, risking reduced contraceptive efficacy. The effect is likely greater with frequent or prolonged use.
How serious is the interaction between Butalbital and Etonogestrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Add a barrier method if butalbital is used regularly, and consider a non-hormonal method for long-term use.
What other medicines interact with Etonogestrel?
MediHelp also lists interactions of Etonogestrel with, for example, Amobarbital, Armodafinil, Bosentan. The full list is on the Etonogestrel page.
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