Drug interactions
Amobarbital + Etonogestrel
Severity: Major
Amobarbital and Etonogestrel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzyme-inducing barbiturates can lower etonogestrel exposure and may cause contraceptive failure with implants or vaginal rings. This is clinically important for pregnancy prevention.
What this interaction means in plain words
Amobarbital and Etonogestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Etonogestrel belongs to Endocrine.
Why it happens
Barbiturate induction of CYP3A4 accelerates progestin metabolism.
What to do
Advise an additional or alternative non-hormonal contraceptive method during amobarbital use and for a period after stopping, or use a non-affected method such as an intrauterine device.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Etonogestrel
Frequently asked questions
Can I take Amobarbital with Etonogestrel?
MediHelp rates the interaction as major. Amobarbital and Etonogestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enzyme-inducing barbiturates can lower etonogestrel exposure and may cause contraceptive failure with implants or vaginal rings. This is clinically important for pregnancy prevention.
How serious is the interaction between Amobarbital and Etonogestrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional or alternative non-hormonal contraceptive method during amobarbital use and for a period after stopping, or use a non-affected method such as an intrauterine device.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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