Drug interactions
Brigatinib + Etonogestrel
Severity: Major
Brigatinib and Etonogestrel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brigatinib may lower etonogestrel concentrations and reduce the reliability of implant or ring contraception. Pregnancy risk matters because brigatinib can harm the fetus.
What this interaction means in plain words
Brigatinib and Etonogestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Brigatinib belongs to Oncology; Etonogestrel belongs to Endocrine.
Why it happens
Brigatinib induces CYP3A4, increasing etonogestrel metabolism.
What to do
Use an effective non-hormonal contraceptive during treatment and for at least 4 months after the last dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Etonogestrel
Other interactions of Brigatinib
Frequently asked questions
Can I take Brigatinib with Etonogestrel?
MediHelp rates the interaction as major. Brigatinib and Etonogestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brigatinib may lower etonogestrel concentrations and reduce the reliability of implant or ring contraception. Pregnancy risk matters because brigatinib can harm the fetus.
How serious is the interaction between Brigatinib and Etonogestrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an effective non-hormonal contraceptive during treatment and for at least 4 months after the last dose.
What other medicines interact with Etonogestrel?
MediHelp also lists interactions of Etonogestrel with, for example, Amobarbital, Armodafinil, Bosentan. The full list is on the Etonogestrel page.
Full monographs, dosing and an interaction checker in the MediHelp app
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