Drug interactions
Bosentan + Etonogestrel
Severity: Major
Bosentan and Etonogestrel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan induces CYP3A4 and may reduce etonogestrel concentrations from the implant or ring, potentially lowering contraceptive efficacy. This matters because bosentan is teratogenic.
What this interaction means in plain words
Bosentan and Etonogestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bosentan belongs to Miscellaneous; Etonogestrel belongs to Endocrine.
Why it happens
Bosentan induces CYP3A4, increasing the metabolism of etonogestrel.
What to do
Do not rely on etonogestrel alone; use an intrauterine device or add a barrier method during and after bosentan therapy. Perform pregnancy testing as indicated.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Etonogestrel
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Cyclosporine Contraindicated
- Bosentan + Glyburide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
Frequently asked questions
Can I take Bosentan with Etonogestrel?
MediHelp rates the interaction as major. Bosentan and Etonogestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bosentan induces CYP3A4 and may reduce etonogestrel concentrations from the implant or ring, potentially lowering contraceptive efficacy. This matters because bosentan is teratogenic.
How serious is the interaction between Bosentan and Etonogestrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not rely on etonogestrel alone; use an intrauterine device or add a barrier method during and after bosentan therapy. Perform pregnancy testing as indicated.
What other medicines interact with Etonogestrel?
MediHelp also lists interactions of Etonogestrel with, for example, Amobarbital, Armodafinil, Brigatinib. The full list is on the Etonogestrel page.
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