Drug interactions
Butalbital + Losartan
Severity: Minor
Butalbital and Losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that may induce hepatic enzymes, which might lower losartan exposure. Clinical effect is probably small with intermittent use.
What this interaction means in plain words
Butalbital and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible induction of CYP2C9 and CYP3A4 by butalbital increasing losartan clearance.
What to do
Monitor blood pressure if butalbital is used regularly and adjust losartan dose if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Butalbital with Losartan?
MediHelp rates the interaction as minor. Butalbital and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butalbital is a barbiturate that may induce hepatic enzymes, which might lower losartan exposure. Clinical effect is probably small with intermittent use.
How serious is the interaction between Butalbital and Losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if butalbital is used regularly and adjust losartan dose if control worsens.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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