Drug interactions
Butalbital + Lovastatin
Severity: Minor
Butalbital and Lovastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital may lower lovastatin concentrations through enzyme induction. This could reduce the cholesterol-lowering effect.
What this interaction means in plain words
Butalbital and Lovastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate induction of CYP3A4 increases lovastatin metabolism.
What to do
Monitor the lipid panel if butalbital is used frequently, and adjust the statin dose or switch to a non-CYP3A4 statin if control is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Frequently asked questions
Can I take Butalbital with Lovastatin?
MediHelp rates the interaction as minor. Butalbital and Lovastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butalbital may lower lovastatin concentrations through enzyme induction. This could reduce the cholesterol-lowering effect.
How serious is the interaction between Butalbital and Lovastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the lipid panel if butalbital is used frequently, and adjust the statin dose or switch to a non-CYP3A4 statin if control is lost.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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