Drug interactions
Butalbital + Paliperidone
Severity: Moderate
Butalbital and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a sedative barbiturate and adds to paliperidone's CNS depressant effects, causing drowsiness and psychomotor impairment. Enzyme induction by the barbiturate may modestly reduce paliperidone exposure.
What this interaction means in plain words
Butalbital and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with possible induction effects of the barbiturate.
What to do
Monitor for oversedation and advise against driving or alcohol. Reassess antipsychotic efficacy if use of butalbital is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Butalbital with Paliperidone?
MediHelp rates the interaction as moderate. Butalbital and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a sedative barbiturate and adds to paliperidone's CNS depressant effects, causing drowsiness and psychomotor impairment. Enzyme induction by the barbiturate may modestly reduce paliperidone exposure.
How serious is the interaction between Butalbital and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and advise against driving or alcohol. Reassess antipsychotic efficacy if use of butalbital is prolonged.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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