Drug interactions
Butalbital + Saxagliptin
Severity: Minor
Butalbital and Saxagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate with CYP3A4-inducing potential that may lower saxagliptin exposure. Intermittent use is unlikely to matter, but regular use could reduce glycemic efficacy.
What this interaction means in plain words
Butalbital and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Induction of CYP3A4/5 by butalbital increases saxagliptin metabolism.
What to do
Monitor glycemic control if butalbital is taken regularly. Adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Butalbital with Saxagliptin?
MediHelp rates the interaction as minor. Butalbital and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butalbital is a barbiturate with CYP3A4-inducing potential that may lower saxagliptin exposure. Intermittent use is unlikely to matter, but regular use could reduce glycemic efficacy.
How serious is the interaction between Butalbital and Saxagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control if butalbital is taken regularly. Adjust antidiabetic therapy if control worsens.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
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