Drug interactions
Butalbital + Sirolimus
Severity: Moderate
Butalbital and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that may induce CYP3A4 and reduce sirolimus concentrations. Intermittent use makes the effect variable, but sustained lowering could risk rejection.
What this interaction means in plain words
Butalbital and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 by butalbital, increasing sirolimus metabolism.
What to do
Prefer an alternative headache therapy if possible. If butalbital is used regularly, monitor sirolimus trough levels and adjust the dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Butalbital with Sirolimus?
MediHelp rates the interaction as moderate. Butalbital and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate that may induce CYP3A4 and reduce sirolimus concentrations. Intermittent use makes the effect variable, but sustained lowering could risk rejection.
How serious is the interaction between Butalbital and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative headache therapy if possible. If butalbital is used regularly, monitor sirolimus trough levels and adjust the dose.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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