Drug interactions
Butalbital + Voriconazole
Severity: Major
Butalbital and Voriconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital, a barbiturate, may reduce voriconazole concentrations and compromise antifungal efficacy. The effect is extrapolated from long-acting barbiturates.
What this interaction means in plain words
Butalbital and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Barbiturate-related induction of CYP2C19 and CYP3A4 increases voriconazole clearance.
What to do
Prefer a headache regimen without butalbital during voriconazole therapy. If used, monitor voriconazole trough levels and clinical response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Butalbital with Voriconazole?
MediHelp rates the interaction as major. Butalbital and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Butalbital, a barbiturate, may reduce voriconazole concentrations and compromise antifungal efficacy. The effect is extrapolated from long-acting barbiturates.
How serious is the interaction between Butalbital and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a headache regimen without butalbital during voriconazole therapy. If used, monitor voriconazole trough levels and clinical response.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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