Drug interactions
Butorphanol + Clomipramine
Severity: Moderate
Butorphanol and Clomipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine adds sedation and anticholinergic effects to opioid therapy, which may cause excessive drowsiness and confusion. Clomipramine also has serotonergic activity, though butorphanol carries little serotonin syndrome risk.
What this interaction means in plain words
Butorphanol and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Butorphanol belongs to Musculoskeletal; Clomipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression from opioid agonism and tricyclic antihistaminic and anticholinergic effects.
What to do
Use the lowest effective doses and monitor for oversedation and respiratory depression. Reduce the opioid dose if drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Butorphanol and Clomipramine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Butorphanol with Clomipramine?
MediHelp rates the interaction as moderate. Butorphanol and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine adds sedation and anticholinergic effects to opioid therapy, which may cause excessive drowsiness and confusion. Clomipramine also has serotonergic activity, though butorphanol carries little serotonin syndrome risk.
How serious is the interaction between Butorphanol and Clomipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation and respiratory depression. Reduce the opioid dose if drowsiness occurs.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
