Drug interactions
Butorphanol + Dexchlorpheniramine
Severity: Moderate
Butorphanol and Dexchlorpheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The sedating antihistamine adds to the CNS depression caused by butorphanol, increasing drowsiness and psychomotor impairment. Anticholinergic effects may add to confusion in older adults.
What this interaction means in plain words
Butorphanol and Dexchlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Butorphanol belongs to Musculoskeletal; Dexchlorpheniramine belongs to Respiratory.
Why it happens
Additive CNS depression from opioid agonism and central H1 receptor blockade.
What to do
Monitor sedation and advise against driving or alcohol. Consider a non-sedating antihistamine, especially in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Dexchlorpheniramine
- Alprazolam + Dexchlorpheniramine Moderate
- Amisulpride + Dexchlorpheniramine Moderate
- Amitriptyline + Dexchlorpheniramine Moderate
- Amobarbital + Dexchlorpheniramine Moderate
- Asenapine + Dexchlorpheniramine Moderate
- Azelastine-fluticasone + Dexchlorpheniramine Moderate
Frequently asked questions
Can I take Butorphanol with Dexchlorpheniramine?
MediHelp rates the interaction as moderate. Butorphanol and Dexchlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The sedating antihistamine adds to the CNS depression caused by butorphanol, increasing drowsiness and psychomotor impairment. Anticholinergic effects may add to confusion in older adults.
How serious is the interaction between Butorphanol and Dexchlorpheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and advise against driving or alcohol. Consider a non-sedating antihistamine, especially in older adults.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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