Drug interactions
Azelastine-fluticasone + Dexchlorpheniramine
Severity: Moderate
Azelastine-fluticasone and Dexchlorpheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexchlorpheniramine is a first-generation sedating antihistamine, so combining it with azelastine duplicates therapy. This may cause additive drowsiness and anticholinergic effects.
What this interaction means in plain words
Azelastine-fluticasone and Dexchlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine-fluticasone belongs to Respiratory; Dexchlorpheniramine belongs to Respiratory.
Why it happens
Additive H1-receptor antagonism and CNS depression.
What to do
Avoid concurrent use of two antihistamines where possible. If used together, monitor for sedation and warn about driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Dexchlorpheniramine
- Alprazolam + Dexchlorpheniramine Moderate
- Amisulpride + Dexchlorpheniramine Moderate
- Amitriptyline + Dexchlorpheniramine Moderate
- Amobarbital + Dexchlorpheniramine Moderate
- Asenapine + Dexchlorpheniramine Moderate
- Azelastine + Dexchlorpheniramine Moderate
Frequently asked questions
Can I take Azelastine-fluticasone with Dexchlorpheniramine?
MediHelp rates the interaction as moderate. Azelastine-fluticasone and Dexchlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexchlorpheniramine is a first-generation sedating antihistamine, so combining it with azelastine duplicates therapy. This may cause additive drowsiness and anticholinergic effects.
How serious is the interaction between Azelastine-fluticasone and Dexchlorpheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two antihistamines where possible. If used together, monitor for sedation and warn about driving.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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