Drug interactions
Amisulpride + Dexchlorpheniramine
Severity: Moderate
Amisulpride and Dexchlorpheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
A first-generation antihistamine combined with amisulpride may produce more sedation and psychomotor impairment than either drug alone. Older patients are at higher risk of confusion and falls.
What this interaction means in plain words
Amisulpride and Dexchlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Dexchlorpheniramine belongs to Respiratory.
Why it happens
Additive CNS depression from H1 antagonism and dopamine D2 antagonism.
What to do
Use a non-sedating antihistamine as an alternative when feasible. Counsel on drowsiness and monitor older patients for confusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Other interactions of Dexchlorpheniramine
- Alprazolam + Dexchlorpheniramine Moderate
- Amitriptyline + Dexchlorpheniramine Moderate
- Amobarbital + Dexchlorpheniramine Moderate
- Asenapine + Dexchlorpheniramine Moderate
- Azelastine-fluticasone + Dexchlorpheniramine Moderate
- Azelastine + Dexchlorpheniramine Moderate
Frequently asked questions
Can I take Amisulpride with Dexchlorpheniramine?
MediHelp rates the interaction as moderate. Amisulpride and Dexchlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. A first-generation antihistamine combined with amisulpride may produce more sedation and psychomotor impairment than either drug alone. Older patients are at higher risk of confusion and falls.
How serious is the interaction between Amisulpride and Dexchlorpheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-sedating antihistamine as an alternative when feasible. Counsel on drowsiness and monitor older patients for confusion.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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