Drug interactions
Asenapine + Dexchlorpheniramine
Severity: Moderate
Asenapine and Dexchlorpheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining asenapine with this sedating antihistamine can cause additive drowsiness and impaired psychomotor performance. Additive anticholinergic effects such as dry mouth and constipation may occur.
What this interaction means in plain words
Asenapine and Dexchlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Dexchlorpheniramine belongs to Respiratory.
Why it happens
Additive CNS depression via H1 antagonism from both drugs, with additive antimuscarinic effects.
What to do
Warn patients about sedation and avoid driving until response is known. Prefer a non-sedating antihistamine where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Dexchlorpheniramine
- Alprazolam + Dexchlorpheniramine Moderate
- Amisulpride + Dexchlorpheniramine Moderate
- Amitriptyline + Dexchlorpheniramine Moderate
- Amobarbital + Dexchlorpheniramine Moderate
- Azelastine-fluticasone + Dexchlorpheniramine Moderate
- Azelastine + Dexchlorpheniramine Moderate
Frequently asked questions
Can I take Asenapine with Dexchlorpheniramine?
MediHelp rates the interaction as moderate. Asenapine and Dexchlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining asenapine with this sedating antihistamine can cause additive drowsiness and impaired psychomotor performance. Additive anticholinergic effects such as dry mouth and constipation may occur.
How serious is the interaction between Asenapine and Dexchlorpheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients about sedation and avoid driving until response is known. Prefer a non-sedating antihistamine where possible.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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