Drug interactions
Butorphanol + Eluxadoline
Severity: Moderate
Butorphanol and Eluxadoline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline is a mu agonist used for IBS with diarrhea, and opioids can cause constipation. Combined use raises the risk of severe constipation and related complications such as ileus, and may reduce eluxadoline's benefit.
What this interaction means in plain words
Butorphanol and Eluxadoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Butorphanol belongs to Musculoskeletal; Eluxadoline belongs to Gastrointestinal Tract.
Why it happens
Additive opioid-receptor-mediated slowing of gastrointestinal motility.
What to do
Avoid regular concurrent use; if butorphanol is needed, stop eluxadoline if severe constipation develops. Monitor bowel function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Eluxadoline
Frequently asked questions
Can I take Butorphanol with Eluxadoline?
MediHelp rates the interaction as moderate. Butorphanol and Eluxadoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eluxadoline is a mu agonist used for IBS with diarrhea, and opioids can cause constipation. Combined use raises the risk of severe constipation and related complications such as ileus, and may reduce eluxadoline's benefit.
How serious is the interaction between Butorphanol and Eluxadoline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular concurrent use; if butorphanol is needed, stop eluxadoline if severe constipation develops. Monitor bowel function.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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