Drug interactions
Diphenoxylate-atropine + Eluxadoline
Severity: Major
Diphenoxylate-atropine and Eluxadoline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline is an opioid receptor modulator whose labeling warns against use with drugs that cause constipation. Diphenoxylate-atropine is strongly constipating and increases the risk of serious complications such as ileus or obstruction.
What this interaction means in plain words
Diphenoxylate-atropine and Eluxadoline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diphenoxylate-atropine belongs to Gastrointestinal Tract; Eluxadoline belongs to Gastrointestinal Tract.
Why it happens
Additive inhibition of gastrointestinal motility via opioid and anticholinergic effects.
What to do
Avoid using the two together. If constipation or abdominal pain develops, stop the agents and assess for ileus.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Other interactions of Eluxadoline
Frequently asked questions
Can I take Diphenoxylate-atropine with Eluxadoline?
MediHelp rates the interaction as major. Diphenoxylate-atropine and Eluxadoline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eluxadoline is an opioid receptor modulator whose labeling warns against use with drugs that cause constipation. Diphenoxylate-atropine is strongly constipating and increases the risk of serious complications such as ileus or obstruction.
How serious is the interaction between Diphenoxylate-atropine and Eluxadoline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using the two together. If constipation or abdominal pain develops, stop the agents and assess for ileus.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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