Drug interactions
Butorphanol + Haloperidol
Severity: Moderate
Butorphanol and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use can increase sedation, dizziness and hypotension, and opioids may add to the CNS depression seen with haloperidol. The effect is usually manageable, but vulnerable patients such as the elderly are at higher risk.
What this interaction means in plain words
Butorphanol and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Butorphanol belongs to Musculoskeletal; Haloperidol belongs to Central Nervous System.
Why it happens
Additive CNS depression from opioid receptor activity and dopamine D2 antagonism.
What to do
Monitor sedation, blood pressure and respiratory rate, and start with reduced doses in older or debilitated patients. Counsel against driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Butorphanol with Haloperidol?
MediHelp rates the interaction as moderate. Butorphanol and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use can increase sedation, dizziness and hypotension, and opioids may add to the CNS depression seen with haloperidol. The effect is usually manageable, but vulnerable patients such as the elderly are at higher risk.
How serious is the interaction between Butorphanol and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and respiratory rate, and start with reduced doses in older or debilitated patients. Counsel against driving.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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