Drug interactions
Butorphanol + Selinexor
Severity: Moderate
Butorphanol and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, confusion, fatigue and other neurological effects. Butorphanol is a sedating opioid that may add to these effects and raise the risk of falls and impaired cognition. No pharmacokinetic interaction is established.
What this interaction means in plain words
Butorphanol and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Butorphanol belongs to Musculoskeletal; Selinexor belongs to Oncology.
Why it happens
Additive pharmacodynamic CNS effects; no established pharmacokinetic mechanism.
What to do
Monitor for dizziness, confusion and sedation and counsel on fall precautions and avoiding driving. Reduce the opioid dose if neurological symptoms worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Butorphanol with Selinexor?
MediHelp rates the interaction as moderate. Butorphanol and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, confusion, fatigue and other neurological effects. Butorphanol is a sedating opioid that may add to these effects and raise the risk of falls and impaired cognition. No pharmacokinetic interaction is established.
How serious is the interaction between Butorphanol and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, confusion and sedation and counsel on fall precautions and avoiding driving. Reduce the opioid dose if neurological symptoms worsen.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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