Drug interactions
Butorphanol + Ziconotide
Severity: Moderate
Butorphanol and Ziconotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziconotide is an intrathecal analgesic that commonly causes dizziness, confusion, and reduced consciousness. Systemic opioids such as butorphanol may add to CNS depression, although ziconotide does not interact directly with opioid receptors.
What this interaction means in plain words
Butorphanol and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Butorphanol belongs to Musculoskeletal; Ziconotide belongs to Central Nervous System.
Why it happens
Additive CNS depression; ziconotide blocks N-type calcium channels while butorphanol acts at opioid receptors.
What to do
Monitor mental status and sedation closely, and reduce doses if cognitive impairment appears. Stop ziconotide if serious neuropsychiatric effects arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Ziconotide
- Clozapine + Ziconotide Major
- Alprazolam + Ziconotide Moderate
- Amitriptyline + Ziconotide Moderate
- Amobarbital + Ziconotide Moderate
- Aripiprazole + Ziconotide Moderate
- Armodafinil + Ziconotide Moderate
Frequently asked questions
Can I take Butorphanol with Ziconotide?
MediHelp rates the interaction as moderate. Butorphanol and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziconotide is an intrathecal analgesic that commonly causes dizziness, confusion, and reduced consciousness. Systemic opioids such as butorphanol may add to CNS depression, although ziconotide does not interact directly with opioid receptors.
How serious is the interaction between Butorphanol and Ziconotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor mental status and sedation closely, and reduce doses if cognitive impairment appears. Stop ziconotide if serious neuropsychiatric effects arise.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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