Drug interactions
Clozapine + Ziconotide
Severity: Major
Clozapine and Ziconotide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziconotide given intrathecally can cause sedation, confusion and psychiatric adverse effects including psychosis, and it carries a warning for severe psychiatric symptoms. Clozapine's own sedation and the underlying psychiatric disease may add to this risk.
What this interaction means in plain words
Clozapine and Ziconotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clozapine belongs to Central Nervous System; Ziconotide belongs to Central Nervous System.
Why it happens
Additive CNS depression and neuropsychiatric effects.
What to do
Avoid ziconotide in patients with a history of psychosis, or monitor closely for sedation, confusion and mood or psychotic changes and stop it if they occur.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Ziconotide
- Alprazolam + Ziconotide Moderate
- Amitriptyline + Ziconotide Moderate
- Amobarbital + Ziconotide Moderate
- Aripiprazole + Ziconotide Moderate
- Armodafinil + Ziconotide Moderate
- Asenapine + Ziconotide Moderate
Frequently asked questions
Can I take Clozapine with Ziconotide?
MediHelp rates the interaction as major. Clozapine and Ziconotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ziconotide given intrathecally can cause sedation, confusion and psychiatric adverse effects including psychosis, and it carries a warning for severe psychiatric symptoms. Clozapine's own sedation and the underlying psychiatric disease may add to this risk.
How serious is the interaction between Clozapine and Ziconotide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ziconotide in patients with a history of psychosis, or monitor closely for sedation, confusion and mood or psychotic changes and stop it if they occur.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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